Whole-brain white matter disruption in semantic and nonfluent variants of primary progressive aphasia
نویسندگان
چکیده
منابع مشابه
White Matter Disruption and Connected Speech in Non-Fluent and Semantic Variants of Primary Progressive Aphasia
Differential patterns of white matter disruption have recently been reported in the non-fluent (nfvPPA) and semantic (svPPA) variants of primary progressive aphasia (PPA). No single measure is sufficient to distinguish between the PPA variants, but connected speech allows for the quantification of multiple measures. The aim of the present study was to further investigate the white matter correl...
متن کاملPrimary progressive aphasia: a comparative study of progressive nonfluent aphasia and semantic dementia.
Primary progressive aphasia (PPA), a degenerative disorder, is often misdiagnosed as Alzheimer's disease. Its subtypes, semantic dementia (SD), and progressive nonfluent aphasia (PNFA), are often difficult to differentiate from each other. Our objective was to highlight the differences in the language profiles of patients with SD and PNFA. To bring out these differences, we report two patients ...
متن کاملThe new classification of primary progressive aphasia into semantic, logopenic, or nonfluent/agrammatic variants.
Primary progressive aphasia (PPA), typically resulting from a neurodegenerative disease such as frontotemporal lobar degeneration or Alzheimer's disease, is characterized by a progressive loss of specific language functions with relative sparing of other cognitive domains. Three variants of PPA are now recognized: semantic variant, logopenic variant, and nonfluent/agrammatic variant. We discuss...
متن کاملTeaching NeuroImages: Nonfluent variant primary progressive aphasia
A 66-year-old woman presented with 4 years of progressive speech difficulty. She had nonfluent speech with phonemic errors but intact single-word comprehension and object knowledge. Her grammar was impaired in both speech and writing, and she exhibited orofacial apraxia. A clinico-radiologic (see figure) diagnosis of nonfluent variant primary progressive aphasia was made. Nonfluent variant prim...
متن کاملSemantic dementia versus nonfluent progressive aphasia: neuropsychological characterization and differentiation.
BACKGROUND Early progressive nonfluent aphasia (PNFA) may be difficult to differentiate from semantic dementia (SD) in a nonspecialist setting. There are descriptions of the clinical and neuropsychological profiles of patients with PNFA and SD but few systematic comparisons. METHOD We compared the performance of groups with SD (n=27) and PNFA (n=16) with comparable ages, education, disease du...
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ژورنال
عنوان ژورنال: Human Brain Mapping
سال: 2011
ISSN: 1065-9471
DOI: 10.1002/hbm.21484